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KMID : 1377020160130020111
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Tissue Engineering and Regenerative Medicine
2016 Volume.13 No. 2 p.111 ~ p.125
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Gene therapy for bone tissue engineering
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Kim Young-Dong
Prasad Pofali
Park Tae-Eun
Bijay Singh
Cho Ki-hyun
Sushila Maharjan
Prajakta Dandekar
Ratnesh Jain
Choi Yun-Jaie
Rohidas Arote
Cho Chong-Su
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Abstract
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Gene therapy holds a great promise and has been extensively investigated to improve bone formation and regeneration therapies in bone tissue engineering. A variety of osteogenic genes can be delivered by combining different vectors (viral or non-viral), scaffolds and delivery methodologies. Ex vivo & in vivo gene enhanced tissue engineering approaches have led to successful osteogenic differentiation and bone formation. In this article, we review recent advances of gene therapy-based bone tissue engineering discussing strengths and weaknesses of various strategies as well as general overview of gene therapy.
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KEYWORD
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Gene therapy, Viral vector, Non-viral vector, Bone tissue engineering, Bone morphogenetic protein
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